Taking Dmg And Tmg Together
Alternative names: Anhydrous Betaine or simply Betaine.
TMG/DMG; This is an holistic view of the gut and brain function. TMG and DMG – Neurological function and immune system. Trimethylglycine (TMG) consists of the amino acid glycine attached to three methyl groups and Dimethylglycine (DMG) is a derivative of TMG and consists of the amino acid glycine attached to two methyl groups. When taking Niacin, it's a matter of balancing benefits, genetics, and need for compensatory support like TMG to keep the system in balance. While researchers of NR are not concerned, others like Chris Masterjohn Ph.D., encourage those taking NR to consider a TMG supplement, or boost glycine intakes like that found in Collagen, Magnesium. TMG comes in tablets or capsules of 500, 750 and 1000 mg. Endomet Labs does not sell TMG at this time, but it is widely available in health food stores and on the internet. Do not take DMG or dimethylglycine. Only take trimethylglycine or TMG. All brands in the stores seem to work well. DMG and TMG help with methylation. With 90% of our kids on the autism spectrum having issues with methylation, which usually result in speech or sensory processing issues, DMG and TMG are great supplements to try. Especially since they have been reported to have a 50% success rate for ASD kids. (read about that here). Other claims include DMG as an energy booster and a stress reducer as well as a treatment to control seizures. The supplement apparently lowers blood cholesterol, blood sugar, and blood pressure. The amino acid derivative is also believed to treat symptoms of attention deficit hyperactivity disorder (ADHD) and chronic fatigue syndrome. Taking high dosages of TMG can possibly cause fishy odors on the breath or in sweat and urine. However, if you feel the need to supplement with TMG and notice the fishy smell, easyazonlink keywords=”riboflavin” locale=”US” tag=”dmgbiz-20″supplementing with riboflavin at 100mg twice a day may get rid of the smell./easyazonlink.
An extract from sugar beets, TMG is a natural polysaccharide and a good source of methyl groups that promotes healthier levels of the powerful pro-oxidant and free radical generator homocysteine. Homocysteine is a toxic end product of the metabolism (methylation) of methionine (an essential amino acid) and is now known to be a leading cause of heart and artery disease. Tubemate apk free download for android 4.4 4.
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TMG is a byproduct of sugar beet processing and is a known methyl donor. Through methyl transfers, betaine is derived from choline and subsequent reactions convert betaine to dimethylglycine. Betaine may influence neurological function indirectly via 5-adenosylmethionine synthesis. Animal studies have demonstrated that supplementary intake of betaine had a 2- to 5-fold increase in SAM concentrations. Hyland et al reported increased SAM concentrations to near normal in a patient suffering from 5,10-methylenetetrahydrofolate reductase (an enzyme involved in the regeneration of methionine) deficiency where initial SAM concentration were undetectable.
Methylation reactions and how they relate to the prevention of many diseases such as cancer, heart disease, liver disease and neurological disorders are a growing area of interest for researchers.
Source
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TMG is in available in powdered form, and is found in many over-the-counter preparations in health food stores.
NOTE: An inexpensive variety is Betaine HCL which acts as a stomach acidifier and is not practical due to stomach irritation at the doses required to enhance methylation metabolism.
Function; Why it is Recommended
In the liver, TMG transfers one of its three methyl groups to homocysteine, which is then converted into the useful amino acidmethionine.
When methylation is working properly, homocysteine is quickly converted back to methionine which is then converted to SAMe (S-adenosylmethionine), which protects the liver and is a natural antidepressant. [2][3] SAMe then acts as a methyl donor for DNA: when attached to DNA, methyl groups appear protective, preventing mutated genes from expressing themselves. [4] It may improve health, reduce the risk of genetically induced cancers, and slow cellular aging. Factors that decrease methylation include smoking, alcohol consumption, high fat diets and birth control pills.
Multiple studies have demonstrated that medium to high levels of plasma homocysteine are associated with increased risk of heart disease, cerebrovascular disease and peripheral artery disease. In one study, daily treatment with TMG, folic acid and choline normalized homocysteine levels in 17 of 19 patients. [1] TMG lowers homocysteine levels with and without vitamins B12, B6 and folic acid.
Along with cofactors such as vitamins B6, B12 and Folic Acid, TMG is part of a chemical contingent in the body that works against cancer, heart and neurological diseases, and nearly every age-related disorder.
TMG is a versatile nutrient and provides an intermediary metabolite that can enable a person or animal to function at more optimum mental and physical levels. It aids the body in overcoming a number of adverse health conditions, and is an intricate part of human metabolism. DMG (TMG's metabolite) has been used as a nutritional supplement for over 25 years. In a broad sense, TMG protects the body from many forms of physical, metabolic and environmental stress.
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Applications include:
- Immune modulation: Improves antibody response, enhances B- and T-cell function, and regulates cytokines.
- Viral/bacterial infections: Enhances immune response.
- Cardiovascular: Reduces cholesterol and triglyceride levels, helps eliminate hypoxia, improves coronary circulation, decreases angina pain.
- Athletic performance: Enhances endurance, improves oxygen utilization, reduces lactic acid buildup, improves muscle recovery.
- Autism/epilepsy: Improves verbal communication/social interaction/lethargy, may reduce seizures.
- Chronic fatigue syndrome: Greater mental alertness and energy, improves immune dysfunction.
- Melanoma: Anti-tumor activity, prevents metastasis.
- Lupus (SLE): Reduces antinuclear antibodies, modulates cytokine production.
- Contributes to DNA stability: As a methyl donor supplement, it helps protect cellular DNA from mutation.
- Liver detoxification
- Brain neurotransmitter production
- Lowering homocysteine levels naturally: Thereby lowers risk of heart and vascular disease.
TMG supplementation may sometimes produce hyperactivity in autistic children. Folic acid appears to help neutralize this effect at one or two 800mcg tablets. [Autism Res Rev Int 10( 3): 7, 1996]
Instructions
The usual TMG dose is 500 to 1,000mg per day – roughly equivalent to what a diet high in broccoli, spinach or beets would provide.
References & Further Information
(1) Dudman, N.P., et al. 'Disordered methionine/homocysteine metabolism in premature vascular disease. Its occurrence, cofactor therapy and enzymology,' Arteriosclerosis and Thrombosis 13(9): 1253-60, 1993
(2) Dudman, N. 'Disordered methionine/homocysteine metabolism in premature vascular disease,' Arteriosclerosis and Thrombosis 13(9): 1253-60, 1993
(3) Kishi, T. 'Effect of betaine on s-adenosylmethionine levels in the cerebrospinal fluid in a patient with methylenetetrahydrofolate reductase deficiency and peripheral neuropathy' J Inherited Metabolic Disease 17(5): 560-5, 1994
(4) Cooney, C. 'Are somatic cells inherently deficient in methylation metabolism?' Growth, Development & Aging 57(4): 261-73, 1993